Cholesterol Metabolism, Ldl, and the Ldl Receptor by N. B. Myant

By N. B. Myant

Ldl cholesterol Metabolism, LDL, and the LDL Receptor

summary: ldl cholesterol Metabolism, LDL, and the LDL Receptor

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Example text

4 4 1 4 T h e H M G - C o A Reductas e G e n e a n dIt s m R N A 25 scripti s converte dint o th efinishe dmRNA . (Th e 3'-splicin gsit ei s alway sa tth e same position , 2 3 nucleotide s upstrea mfro mth eA o f th e initiato rcodon. ) Fou r of th e eigh tstartpoints us e th e sam e 5'-splicin g site , bu teac ho f th e remainin g fourstartpoint s ca nus e thre edifferen tsplicin g sites . Thi s give sa tota lo f1 6 different5'-untranslatedregion s varyin gi nlengt hfor m6 8 t o 67 0 nucleotide s andcontainin g 3 , 6 , o r8 ATG s upstrea mfro mth e initiato rcodon .

The abov e mode li sfull y applicabl e onl y t o mature cells . Th e markedincreas e inHMG-Co A reductas e activit y tha toccur si nth e cell so f man y developin g tissues ma y b e explaine dpartl yb ya respons e t o increase dutilizatio no ffre e cholesterolfo rmembran e formation ,a si ndevelopin g nerv e tissu e undergoin g myelinization. However ,i nmos tcase sa developmenta l increas ei nreductas e activityi s bes tsee na sa reflectio no f th e switchin go nan dof fo f gene s tha t underlies th e developmen to fal ldifferentiatedorganisms .

Th e increas ei nenzym e synthesis tha toccur si ncell s incubate dwit hlecithi no rHD Li s probabl ya response t o withdrawalo f cholestero lfro mth e cell sb y thes e tw o acceptor sfo r free cholestero l (se e Rothblat , 1969) . Cohenet al. (1982) ,o nth e basi so f thei rstudie so f vascula rendothelia l cell s inculture , conclud e tha tHD Lan dcompacti ninduc e HMG-Co A reductas e b y differentmechanisms . LD Lreverse s inductio nb y HD Lbu tdoe s no trevers e tha t broughtabou tb y compactin .

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