Cell Adhesion Molecules in Human Transplantation (Medical by Gustav Steinhoff

By Gustav Steinhoff

Scientific university Hannover, Germany. presents a large survey approximately most modern examine in expression and induction of assorted intercellular adhesion molecules in medical kidney, liver, center, and lung transplantation. For researchers.

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1. 247 The gene region contains 3500 base pairs (bottom). Defined genes with known HLA-antigen products are black, so far undefined genes are white. Between the genes for HLA class I and class II molecules additional genes coding for 21-hydroxylase, complement factors 2, 4 and Bf as for Tumor Necrosis Factor (TNF) are located. biopsies have been taken of liver in different pathological states and in sequence after liver transplantation. This allowed the study of changes in MHC antigen expression during rejection and other complications and under immunosuppressive drug treatment.

212,239 In some kidneys where generalized, upregulated HLA-DR antigen expression was detected on all renal tubules, HLA-DP and DQ antigens were only detected on the proximal tubules. It is possible that the proximal and distal tubules have a differing susceptibility to induction. 25,84,239,241,284,308,320 As described above, the tubules in the vicinity of focal infiltration frequently express upregulated levels of class II, while normal levels persist in other areas of the biopsy, suggesting that the upregulation is caused by cytokines, probably interferon-γ, released locally from activated leukocytes.

L-selectin homophilic; αE/β7 are single stranded cell membrane molecules (CD2, Meuer et al;518 LFA-3, Springer et al,743 Meuer and Resch;517 ICAM-1, Rothlein et al,658 Marlin and Springer,494 Makgoba et al;487 ICAM-2, De Fougerolles et al,181 Seth et al;705 ICAM-3, De Fougerolles et al;180 VCAM-1, Osborn et al,576 Rice et al,637-639 Elices et al;210 NCAM, Hercend et al,321 Lanier et al;431 PECAM/CD31, Simmonds et al,717 Albeda et al,15 Liao et al,469 Metzelaar et al515). These molecules exert different functions in intercellular adhesion, transendothelial migration, transmembrane signaling, cell activation processes.

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