By Alan H. B. Wu
Univ. of Connecticut, Hartford. Demonstrates the makes use of of cardiac markers in treating coronary artery disorder and their use in scientific settings. additionally discusses using natriuretic peptides for congestive middle failure. Covers new facts on ischemic and genetic markers. prior variation: c1998. DNLM: Myocardial Infarction--diagnosis.
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Inhibition of platelet Glycoprotein IIb/IIIa with eptifibatide in patients with acute coronary syndromes. The PURSUIT Trial Investigators. Platelet Glycoprotein IIb/IIIa in Unstable Angina: receptor Suppression Using Integrilin Therapy. N Engl J Med 1998;339:436–443. 52. Comparison of Aspirin Plus Tirofiban With Aspirin Plus Heparin for Unstable Angina Platelet Receptor Inhibition in Ischemic Syndrome Management (PRISM) Study Investigators. N Engl J Med 5-21-1998;338(21):1498–1505. 53. Heeschen C, Hamm CW, Goldmann B, Deu A, Langenbrink L, White HD.
1% C-Reactive Protein Instability of coronary plaques is associated with macrophage accumulation (9), inflammation, and an increase in acute phase proteins such as high-sensitivity CRP and serum amyloid A (10). High concentration of both baseline (11–16) and discharge (17) high-sensitivity CRP are independent predictors of subsequent events (11,12,18). CRP and cardiac troponin have been shown to be independent and additive in the prediction of cardiac death (13,19). Although high-sensitivity commercial assays required to detect minimal increases of CRP have only recently been released, the concentrations of CRP Management of Acute Coronary Syndromes 19 Fig.
The FRISC II study (77) examined an early invasive strategy in 2457 patients with unstable angina who had ECG changes or positive serum markers. 03) at 6 mo, compared with a conservative strategy in which revascularization was driven by recurrent or ongoing ischemia. The event curves continued to diverge at 6 mo after randomization. 10). Total mortality 28 Aroney and de Lemos was significantly reduced in men but not in women treated with the invasive strategy. 05) at 6 mo. 001) in the invasive compared with the noninvasive group.