Burkitt’s Lymphoma by Ian Magrath (auth.), Erle S. Robertson (eds.)

By Ian Magrath (auth.), Erle S. Robertson (eds.)

The examine of Burkitt’s lymphoma is now in its 6 decade starting with its discovery by way of Dr. Dennis Burkitt in equatorial Africa within the mid to past due 1950’s. a wide physique of data is offered which supplies a present realizing of the underlying molecular adjustments which are associated with the initiation and improvement of Burkitt’s lymphoma. This proposed quantity will supply a entire view of Burkitt’s Lymphoma from the analysis to power animal versions for this sickness and contain a view from physicians who've a up shut view of the sufferers in populations the place the ailment is rampant. we predict that this can be a great source for scientific scholars and college in addition to proficient laypersons who've an individual curiosity within the disease.

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Extra resources for Burkitt’s Lymphoma

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Moormann AM, Heller KN, Chelimo K et al (2009) Children with endemic Burkitt lymphoma are deficient in EBNA1-specific IFN-gamma T cell responses. Int J Cancer 124(7):1721–1726 58. Geser A, de Thé G, Lenoir G, Day NE, Williams EH (1982) Final case reporting from the Ugandan prospective study of the relationship between EBV and Burkitt’s lymphoma. Int J Cancer 29(4):397–400 59. Pavri R, Nussenzweig MC (2011) AID targeting in antibody diversity. Adv Immunol 110:1–26 60. Kelly GL, Milner AE, Baldwin GS, Bell AI, Rickinson AB (2006) Three restricted forms of Epstein–Barr virus latency counteracting apoptosis in c-myc-expressing Burkitt lymphoma cells.

BL is especially suspect worldwide in immune deficiency conditions such as HIV/AIDS, post solid organ transplants, and following chemotherapy for other malignant lymphomas [5]. The anatomical site of presentation in these nonendemic cases is unlikely to be facial and more likely to be abdominal. Ileo-colic intussusception may present as acute appendicitis even before an underlying BL tumor mass is clinically obvious [6]. BL may be primary in the stomach in association with Helicobacter pylori [7] and in gastric lymph nodes with erosion into the stomach [5]; primary in the wall of the colon [8] and in a variety of other abdominal 2 Diagnosis of Burkitt Lymphoma 37 organs, as primary or as part of multisite BL disease.

Radiation therapy was also studied in Africa, even though radiation was available only in Nairobi in the 1970s—a cobalt unit, as well as expert local supervision in the guise of Swedish radiotherapists, was installed in the Kenyatta National Hospital in Nairobi, Kenya [101]. Single daily dose radiation therapy was shown to be quite ineffective for the control of local disease (with remission occurring in only one of nine irradiated tumors), although hyperfractionation appeared to be of somewhat more benefit.

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