Arterial Stiffness: Implications and Interventions by Bradley S. Fleenor, Adam J. Berrones

By Bradley S. Fleenor, Adam J. Berrones

Arterial stiffness is an rising possibility issue with vital implications for heart problems possibility. Herein, we concisely summarize the physiological and pathophysiological features of arterial stiffening, and spotlight the significance of elevated arterial stiffness for destiny cardiovascular occasions. components contributing to elevated arterial stiffness corresponding to advancing age, weight problems, race, intercourse modifications and cardiorespiratory health are tested whereas elucidating the capability underlying mechanisms for every state of affairs. To finish, we speak about novel interventions to avoid and/or opposite the arterial stiffening procedure in an effort to decrease cardiovascular possibility.

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057232 References 39 38. Pierce GL, Zhu H, Darracott K, Edet I, Bhagatwala J, Huang Y, Dong Y (2013) Arterial stiffness and pulse-pressure amplification in overweight/obese African-American adolescents: relation with higher systolic and pulse pressure. Am J Hypertens 26(1):20–26. 1093/ ajh/hps014 39. Huynh Q, Blizzard L, Sharman J, Magnussen C, Schmidt M, Dwyer T, Venn A (2013) Relative contributions of adiposity in childhood and adulthood to vascular health of young adults. Atherosclerosis 228(1):259–264.

J Am Coll Cardiol 55(13):1318–1327. 061 13. Vlachopoulos C, Ioakeimidis N, Aznaouridis K, Terentes-Printzios D, Rokkas K, Aggelis A, Panagiotakos D, Stefanadis C (2014) Prediction of cardiovascular events with aortic stiffness in patients with erectile dysfunction. Hypertension 64(3):672–678. 03369 14. Vasan RS (2006) Biomarkers of cardiovascular disease: molecular basis and practical considerations. Circulation 113(19):2335–2362. 482570 15. Vigen R, Maddox TM, Allen LA (2012) Aging of the United States population: impact on heart failure.

Thus, examining the role of NFκB in arterial stiffness, and identifying novel interventions to modulate NFκB expression are promising [20, 34]. For example, inhibition of NFκB in older animals improves endothelium-dependent dilation via a NO-dependent mechanism. This finding indirectly suggests NFκB contributes to age-related aortic stiffness by reducing NO bioavailability and impairing endothelial function. As such, anti-inflammatory interventions may lead to reductions in aortic stiffness. Nitric Oxide (NO) Impaired endothelium-dependent dilation is a key functional outcome contributing to arterial stiffness.

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