By Jose A. Plaza, Victor G. Prieto
This booklet presents a complete, cutting-edge account of the position of immunohistochemistry within the analysis of epidermis tumors, that is the most important on condition that overlapping histologic positive factors and weird morphologic adjustments can result in significant diagnostic uncertainty. The e-book experiences intimately the sensitivity and specificity of quite often to be had antibodies and their trend of immunostaining. readers will study while to reserve antibodies and the way to interpret findings. additionally, prognostic markers are evaluated and emphasis put on the pitfalls in most cases encountered whilst comparing those neoplasms. The textual content is complemented by way of a wealth of fabulous pictures. necessary histograms and algorithms are integrated, and transparent assistance is equipped at the software and interpretation of much less time-honored antibodies and immunostains. Applied Immunohistochemistry within the evaluate of epidermis Neoplasms will function a very priceless source for practising dermatopathologists and pathologists.
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Extra info for Applied Immunohistochemistry in the Evaluation of Skin Neoplasms
A conspicuous feature of apocrine secretory cells is their “decapitation” mode of secretion whereby an apical cap, formed at the luminal border of the apocrine cells, separates off from the cell and is discharged into the lumen. Another typical feature of these cells is the presence of intracytoplasmic small, brightly eosinophilic granules (zymogen granules) in a supranuclear location. Zymogen granules are PAS-positive and diastase resistant, and represent lysosomes that contain sialomucin, lipid, and iron.
Clarke LE, et al. 2 and Ber-Ep4 in cutaneous squamous cell carcinoma. J Cutan Pathol. 2013;40(7):646–50. 69. Currie GP, Plaza JA, Harris GJ. Intraepithelial sebaceous carcinoma: a case report of an unusual occurrence. Am J Dermatopathol. 2014;36(8):673–6. 70. Raju RR, Goldblum JR, Hart WR. Pagetoid squamous cell carcinoma in situ (pagetoid Bowen’s disease) of the external genitalia. Int J Gynecol Pathol. 2003;22(2):127–35. 71. Tan BH, Busam KJ, Pulitzer MP. Combined intraepidermal neuroendocrine (Merkel cell) and squamous cell carcinoma in situ with CM2B4 negativity and p53 overexpression(*).
77. Ashida A, et al. Low p53 positivity in verrucous skin lesion in diabetic neuropathy occurring on the dorsum of the foot. Int J Dermatol. 2013;52(3):378–80. 78. Sigel JE, et al. The utility of cytokeratin 5/6 in the recognition of cutaneous spindle cell squamous cell carcinoma. J Cutan Pathol. 2001;28(10):520–4. 79. Gray Y, et al. Squamous cell carcinoma detected by high-molecular-weight cytokeratin immunostaining mimicking atypical fibroxanthoma. Arch Pathol Lab Med. 2001;125(6):799–802. 80.