Apoptosis in Health and Disease: Clinical and Therapeutic by Martin Holcik, Eric C. LaCasse, Alex E. MacKenzie, Robert G.

By Martin Holcik, Eric C. LaCasse, Alex E. MacKenzie, Robert G. Korneluk

The method of programmed phone demise or apoptosis has, within the decade previous the ebook of this 2005 e-book, been proven to be centrally all in favour of the pathogenesis of the numerous majority of human health problems and damage states. The mobile attrition saw in such a lot degenerative stipulations is apoptotic in nature; conversely a failure of apoptosis has been proposed to underlie many varieties of melanoma. The significant position of apoptosis in human ailment truly brings with it medical promise; for instance, the powerful hazard exists that attenuation of apoptotic demise will considerably modulate the severity of degenerative problems. equally, stipulations, similar to melanoma, autoimmune affliction, psoriasis and endometriosis, within which aberrant mobile proliferation is saw, could benefit from more suitable charges of apoptosis. This e-book surveys the underlying molecular mechanisms of apoptosis, investigates its function in degenerative and different ailments, and evaluates power remedies that might allow applicable activation or inhibition of apoptosis in disorder and harm states.

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Med. Chem. , 12, 2969–71. , Fong, W. , Kelly, N. L. et al. (2001). Identification of XAF1 as an antagonist of XIAP anti-caspase activity. Nat. , 3, 128–33. , Tamai, K. et al. (1996). Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. Nature, 379, 349–53. , Ruskone-Fourmestraux, A. et al. (2002). T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication. Gastroenterology, 122, 1286–94. , and Godzik, A. (2003). Homology modeling provides insights into the binding mode of the PAAD/DAPIN/pyrin domain, a fourth member of the CARD/DD/DED domain family.

Sci. , 14, 145–51. Linton, S. , Karanewsky, D. , Ternansky, R. J. et al. (2002). Acyl dipeptides as reversible caspase inhibitors. Part 1: initial lead optimization. Bioorg. Med. Chem. , 12, 2969–71. , Fong, W. , Kelly, N. L. et al. (2001). Identification of XAF1 as an antagonist of XIAP anti-caspase activity. Nat. , 3, 128–33. , Tamai, K. et al. (1996). Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. Nature, 379, 349–53. , Ruskone-Fourmestraux, A. et al. (2002).

2002). Apoptosis: biochemical aspects and clinical implications. Clin. Chim. , 326, 27–45. , Mathialagan, S. et al. (2003). A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts. J. Biol. , 278, 32861–71. , and Zhivotovsky, B. (2002). Evaluation of caspase activity in apoptotic cells. J. Immunol. Methods, 265, 97–110. Komarov, P. , Komarova, E. , Kondratov, R. V. et al. (1999). A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy.

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