By Kara McMahon, Christopher (ILT) Moroney Christopher Moroney
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Arsenic trioxide (ATO) is an alternative differentiating agent that has been particularly used in cases that do not respond to ATRA and in those that harbor the t(11;17). Although experience with ATO in children is limited, the results of its use as single agent are similar to those obtained with ATRA plus chemotherapy, with minimal toxicity (Zhou et al. 2010; George et al. 2004). The intensive chemotherapy regimens often result in significant toxicity and relatively high rates of treatment-related deaths.
1976;33:451–8. Buffler PA, Kwan ML, Reynolds P, Urayama KY. Environmental and genetic risk factors for childhood leukemia: appraising the evidence. Cancer Invest. 2005;23:60–75. Gloeckler L, Percy C, Bunin GR. Introduction. In: Cancer incidence and survival among children and adolescents: United States SEER Program 1975–1995. Bethesda: Surveillance Epidemiology and End Results. US Department of Health & Human Services. NIH Publication (99–4649). 1999. p. 1–16. Harris NL, Jaffe ES, Stein H, et al.
Arya LS, Padmanjali KS, Sazawal S, et al. Childhood T-lineage acute lymphoblastic leukemia: management and outcome at a tertiary care center in North India. Indian Pediatr. 2011;48:785–90. Asim M, Zaidi A, Ghafoor T, Qureshi Y. Death analysis of childhood acute lymphoblastic leukaemia; experience at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Pakistan. J Pak Med Assoc. 2011;61:666–70. Avramis VI, Sencer S, Periclou AP, et al. A randomized comparison of native Escherichia coli asparaginase and polyethylene glycol conjugated asparaginase for treatment of children with newly diagnosed standard-risk acute lymphoblastic leukemia: a Children’s Cancer Group study.