Androgenetic Alopecia: Modern Concepts of Pathogenesis and by Masumi Inaba M.D., Yoshikata Inaba M.D. (auth.)

By Masumi Inaba M.D., Yoshikata Inaba M.D. (auth.)

The authors have perfected a thick-tissue guidance strategy for watching hair at a variety of levels of development, and their findings problem the presently held three-stage universal hair cycle. they've got recommend a brand new speculation, the four-stage crucial hair cycle, that comes with their discovery that stem cells can be found within the isthmal section of the sebaceous gland. the basic hair cycle is then used to study the criteria contributing to the method of androgenetic alopecia, or untimely balding, because it is often known as. this is often through an evidence of a few common measures for the prevention of androgenetic alopecia and an outline of the remedies to be had.

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Additional info for Androgenetic Alopecia: Modern Concepts of Pathogenesis and Treatment

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Preparation of Thick Tissue Specimens Generation and Growth of Human Hair 3 Detailed observations of the generation of fetal eyebrow hair are the most effective means of studying the process by which the human hair follide is first formed. To understand the process by which human hair is generated, it is important to review how the hair is genera ted in the fetus during gestation. The observations made by Inaba et al. (l981a) and Inaba (l983b) of thick tissue specimens revealed the various stages in the development of original fetal eyebrow hair (Fig.

Undifferentiated epidermis. The germ cells within the epidermis become noticeably swollen, or enlarged in the shape of a scallop shell, and are referred to collectively as the "primitive hair germ" (Fig. 2). This primitive hair germ forms at the end of the 2nd or the beginning of the 3rd month of gestation in the eyebrow region and on the upper lip and the chin. The factors determining the sites of individual hair formations are unknown. The initiation and development of hair follides is thought to occur as a consequence of interactions between the epidermis and dermis during fetal life.

The sebaceous gland, which is already formed in the hair peg stage, is then dearly differentiated to form sebum in the bulbous peg stage. This formation of a cyst that subsequently acts as a hair canal protects the new young hair apex (Fig. 9b). Pigmentation of Hair The most important component of human hair (and skin) coloration is the melanosome. This cytoplasmic organelle, on which brown bio chrome melanin is synthesized and deposited, is largely responsible for skin color according to its size, type, color, and distribution in the skin.

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