2010-2011 Nelson's Pocket Book of Pediatric Antimicrobial by John S. Bradley MD, John D. Nelson MD Emeritus

By John S. Bradley MD, John D. Nelson MD Emeritus

This best-selling and favourite source on pediatric antimicrobial treatment offers speedy entry to trustworthy, up to date options for remedy of all infectious illnesses in youngsters. for every sickness, the authors supply a observation to aid well-being care companies pick out the simplest of all antimicrobial offerings. Drug descriptions disguise all antimicrobial brokers on hand this day and contain whole information regarding dosing regimens. in accordance with transforming into matters approximately overuse of antibiotics, this system comprises instructions on while to not prescribe antimicrobials. Key positive aspects: designed in case you look after kids and are confronted with judgements each day; contains therapy of parasitic infections and tropical drugs; up-to-date anti-infective drug directory, whole with formulations and dosages; and balanced info on protection, efficacy, and tolerability with info on expenditures and availability of drugs.

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Additional resources for 2010-2011 Nelson's Pocket Book of Pediatric Antimicrobial Therapy

Example text

Cultures are critical. Empiric therapy also monas, and gram-positive based on child’s prior colonization/infection. 5 mg/kg/day IM, IV div q8h (AII), OR cefepime aminoglycoside.

AIII) 21 d. CT scan to confirm cure. 5 mg/kg/day IM, IV, or amikacin 15–20 mg/kg/ alternatives (no clinical data). Very poor outcomes. day IM, IV div q8h x 10–14 d (AIII) Ceftriaxone 50 mg/kg q24h IV, IM (AIII) Treatment course x 10–14 d – Staphylococcal Vancomycin 40 mg/kg/day IV div q8h pending susceptibility testing; oxacillin 150 mg/kg/day IV div q6h if susceptible (AIII) – Empiric therapy following Vancomycin 40 mg/kg/day IV div q8h AND ceftazidime open globe injury 150 mg/kg/day IV div q8h (AIII) Endophthalmitis56,57 NOTE: Subconjunctival/subtenon antibiotics usually needed; steroids commonly used; Refer to ophthalmologist; vitrectomy may be necessary for requires anterior chamber or vitreous tap for microbiological diagnosis advanced endophthalmitis Dacryocystitis No antibiotic usually needed; oral therapy for more Warm compresses; may require surgical probing of symptomatic infection, based on Gram stain and nasolacrimal duct culture of pus; topical therapy as for conjunctivitis may be helpful Conjunctivitis, herpetic54,55 Trifluridine 1% ophth soln OR acyclovir 3% ophth Refer to ophthalmologist.

Indd 25 Wound cleaning and debridement vital IVIG (200–400 mg/kg) is an alternative if TIG not available; equine tetanus antitoxin not available in US but is alternative to TIG Corticosteroids (1 mg/kg/day div q12h) if active chorioretinitis or CSF protein >1 g/dL (AIII) Start sulfa after neonatal jaundice has resolved. Therapy is only effective against active trophozoites, not cysts. Metronidazole IV/PO (alternative: penicillin G IV) x 10–14 d (AIII) Human TIG 3,000–6,000 U IM x 1 (AIII) Sulfadiazine 100 mg/kg/day PO div q12h AND pyrimethamine 2 mg/kg PO daily x 2 (loading dose), then 1 mg/kg PO q24h for 2–6 months, then 3 times weekly (M-W-F) up to 1 yr (AIII) Folinic acid (leukovorin) 10 mg 3 times weekly (AIII) Initial empiric therapy with ampicillin AND gentamicin; OR ampicillin AND cefotaxime pending culture and susceptibility test results x 7–10 days Tetanus neonatorum88 Toxoplasmosis, congenital89,90 Urinary tract infection91 Ampicillin used for susceptible organisms Aminoglycoside needed with ampicillin or vancomycin for bactericidal activity (assuming organisms susceptible to an aminoglycoside).

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